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Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM50237955
Substrate
n/a
Meas. Tech.
ChEMBL_463142 (CHEMBL929054)
IC50
48700±n/a nM
Citation
 Park, H; Jung, SK; Jeong, DG; Ryu, SE; Kim, SJ Discovery of novel PRL-3 inhibitors based on the structure-based virtual screening. Bioorg Med Chem Lett 18:2250-5 (2008) [PubMed]  Article
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM50237955
Synonyms:
(Z)-5-((2-methyl-2H-chromen-3-yl)methylene)-2-((E)-styryl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one | CHEMBL258009
Type:
Small organic molecule
Emp. Form.:
C23H17N3O2S
Mol. Mass.:
399.465
SMILES:
CC1Oc2ccccc2C=C1\C=c1/sc2nc(\C=C\c3ccccc3)nn2c1=O |w:1.0,c:10|
Structure:
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