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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50259895
Substrate
n/a
Meas. Tech.
ChEMBL_526200 (CHEMBL974769)
IC50
>50000±n/a nM
Citation
 Puder, C; Wagner, K; Vettermann, R; Hauptmann, R; Potterat, O Terphenylquinone inhibitors of the src protein tyrosine kinase from Stilbella sp. J Nat Prod 68:323-6 (2005) [PubMed]  Article
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50259895
Synonyms:
2,5-Dihydroxy-3,6-diphenyl-1,4-benzoquinone | CHEMBL480678
Type:
Small organic molecule
Emp. Form.:
C18H12O4
Mol. Mass.:
292.2855
SMILES:
O=C1C(C(=O)C(=O)C(C1=O)c1ccccc1)c1ccccc1 |(-5.28,2.61,;-4.44,1.32,;-5.14,-.05,;-4.31,-1.35,;-5.01,-2.72,;-2.77,-1.27,;-1.94,-2.57,;-2.07,.09,;-2.9,1.39,;-2.2,2.76,;-.53,.17,;.3,-1.13,;1.83,-1.06,;2.54,.31,;1.7,1.61,;.17,1.53,;-6.68,-.13,;-7.52,1.16,;-9.05,1.09,;-9.76,-.28,;-8.93,-1.58,;-7.38,-1.51,)|
Structure:
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