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Target
Thymidylate kinase
Ligand
BDBM50271535
Substrate
n/a
Meas. Tech.
ChEMBL_556416 (CHEMBL954908)
Ki
92000±n/a nM
Citation
 Gasse, C; Douguet, D; Huteau, V; Marchal, G; Munier-Lehmann, H; Pochet, S Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity. Bioorg Med Chem 16:6075-85 (2008) [PubMed]  Article
Target
Name:
Thymidylate kinase
Synonyms:
CDC8 | DTYMK | KTHY_HUMAN | TMPK | TYMK
Type:
PROTEIN
Mol. Mass.:
23824.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_946051
Residue:
212
Sequence:
MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKKSDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQPDVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDASKSIEAVHEDIRVLSEDAIRTATEKPLGELWK
  
Inhibitor
Name:
BDBM50271535
Synonyms:
6-(4-((5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)hexanoic acid | CHEMBL449771
Type:
Small organic molecule
Emp. Form.:
C17H19BrN2O4
Mol. Mass.:
395.248
SMILES:
OC(=O)CCCCCc1ccc(Cn2cc(Br)c(=O)[nH]c2=O)cc1
Structure:
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