Reaction Details  Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50242924
Substrate
n/a
Meas. Tech.
ChEMBL_491669 (CHEMBL946387)
IC50
1750±n/a nM
Citation
 Chen, N; Bürli, RW; Neira, S; Hungate, R; Zhang, D; Yu, V; Nguyen, Y; Tudor, Y; Plant, M; Flynn, S; Meagher, KL; Lee, MR; Zhang, X; Itano, A; Schrag, M; Xu, Y; Ng, GY; Hu, E Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett 18:4137-41 (2008) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50242924
Synonyms:
4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethyl)phenyl)isophthalamide | CHEMBL512840
Type:
Small organic molecule
Emp. Form.:
C20H15F3N4O2
Mol. Mass.:
400.3539
SMILES:
Cc1ccc(cc1C(=O)Nc1cncnc1)C(=O)Nc1cccc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: