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Target
DNA polymerase I, thermostable
Ligand
BDBM50253657
Substrate
n/a
Meas. Tech.
ChEMBL_512487 (CHEMBL966977)
EC50
10000±n/a nM
Citation
 Zagotto, G; Sissi, C; Lucatello, L; Pivetta, C; Cadamuro, SA; Fox, KR; Neidle, S; Palumbo, M Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. J Med Chem 51:5566-74 (2008) [PubMed]  Article
Target
Name:
DNA polymerase I, thermostable
Synonyms:
DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA
Type:
PROTEIN
Mol. Mass.:
93906.95
Organism:
Thermus aquaticus
Description:
ChEMBL_1289218
Residue:
832
Sequence:
MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGDAVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
  
Inhibitor
Name:
BDBM50253657
Synonyms:
(S)-2-Amino-5-guanidino-pentanoic acid ({6-[2-((S)-2-amino-5-guanidino-pentanoylamino)-acetylamino]-9,10-dioxo-9,10-dihydro-anthracen-2-ylcarbamoyl}-methyl)-amide | CHEMBL502112
Type:
Small organic molecule
Emp. Form.:
C30H40N12O6
Mol. Mass.:
664.7154
SMILES:
[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-c1ccc2-[#6](=O)-c3cc(-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])ccc3-[#6](=O)-c2c1 |r|
Structure:
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