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Target
Egl nine homolog 1
Ligand
BDBM50264220
Substrate
n/a
Meas. Tech.
ChEMBL_535338 (CHEMBL983464)
IC50
3±n/a nM
Citation
 Frohn, M; Viswanadhan, V; Pickrell, AJ; Golden, JE; Muller, KM; Bürli, RW; Biddlecome, G; Yoder, SC; Rogers, N; Dao, JH; Hungate, R; Allen, JR Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors. Bioorg Med Chem Lett 18:5023-6 (2008) [PubMed]  Article
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50264220
Synonyms:
2-(1,6-diphenyl-1H-imidazo[4,5-c]pyridine-4-carboxamido)acetic acid | CHEMBL522419
Type:
Small organic molecule
Emp. Form.:
C21H16N4O3
Mol. Mass.:
372.3767
SMILES:
OC(=O)CNC(=O)c1nc(cc2n(cnc12)-c1ccccc1)-c1ccccc1
Structure:
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