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Target
Melatonin receptor type 1B
Ligand
BDBM50263715
Substrate
n/a
Meas. Tech.
ChEMBL_535636 (CHEMBL987964)
Ki
43.3±n/a nM
Citation
 Poissonnier-Durieux, S; Ettaoussi, M; Pérès, B; Boutin, JA; Audinot, V; Bennejean, C; Delagrange, P; Caignard, DH; Renard, P; Berthelot, P; Lesieur, D; Yous, S Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands. Bioorg Med Chem 16:8339-48 (2008) [PubMed]  Article
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50263715
Synonyms:
3-(4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl)benzoic acid | CHEMBL490594
Type:
Small organic molecule
Emp. Form.:
C22H21NO4
Mol. Mass.:
363.4064
SMILES:
COc1ccc2cc(cc(CCNC(C)=O)c2c1)-c1cccc(c1)C(O)=O
Structure:
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