Reaction Details  Report a problem with these data
Target
Tyrosine-protein kinase Lck
Ligand
BDBM50263476
Substrate
n/a
Meas. Tech.
ChEMBL_535871 (CHEMBL994991)
IC50
789±n/a nM
Citation
 Zhang, G; Ren, P; Gray, NS; Sim, T; Liu, Y; Wang, X; Che, J; Tian, SS; Sandberg, ML; Spalding, TA; Romeo, R; Iskandar, M; Chow, D; Martin Seidel, H; Karanewsky, DS; He, Y Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I. Bioorg Med Chem Lett 18:5618-21 (2008) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50263476
Synonyms:
CHEMBL477590 | N-(2-chloro-6-methylphenyl)-1-(6-(4-(diethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-amine
Type:
Small organic molecule
Emp. Form.:
C26H32ClN7
Mol. Mass.:
478.032
SMILES:
CCN(CC)CCCCNc1cc(ncn1)-n1c(Nc2c(C)cccc2Cl)nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: