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Target
Tyrosine-protein kinase Lyn
Ligand
BDBM50263514
Substrate
n/a
Meas. Tech.
ChEMBL_535873 (CHEMBL994993)
IC50
215±n/a nM
Citation
 Zhang, G; Ren, P; Gray, NS; Sim, T; Liu, Y; Wang, X; Che, J; Tian, SS; Sandberg, ML; Spalding, TA; Romeo, R; Iskandar, M; Chow, D; Martin Seidel, H; Karanewsky, DS; He, Y Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I. Bioorg Med Chem Lett 18:5618-21 (2008) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM50263514
Synonyms:
CHEMBL473250 | N-(2-chloro-6-methylphenyl)-1-(6-(5-(2-morpholinoethyl)pyridin-2-ylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-amine
Type:
Small organic molecule
Emp. Form.:
C29H29ClN8O
Mol. Mass.:
541.047
SMILES:
Cc1cccc(Cl)c1Nc1nc2ccccc2n1-c1cc(Nc2ccc(CCN3CCOCC3)cn2)ncn1
Structure:
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