Reaction Details  Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50274336
Substrate
n/a
Meas. Tech.
ChEMBL_537141 (CHEMBL989801)
IC50
1000±n/a nM
Citation
 Oslund, RC; Cermak, N; Verlinde, CL; Gelb, MH Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. Bioorg Med Chem Lett 18:5415-9 (2008) [PubMed]  Article
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50274336
Synonyms:
1-{3-Dodecanoyl-2,4,6-trihydroxy-5-[7-hydroxy-2-(4-hydroxy-phenyl)-chroman-4-yl]-phenyl}-dodecan-1-one | CHEMBL444450 | YM-26734
Type:
Small organic molecule
Emp. Form.:
C45H62O8
Mol. Mass.:
730.969
SMILES:
CCCCCCCCCCCC(=O)c1c(O)c(C2CC(Oc3cc(O)ccc23)c2ccc(O)cc2)c(O)c(C(=O)CCCCCCCCCCC)c1O
Structure:
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