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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50246306
Substrate
n/a
Meas. Tech.
ChEMBL_557972 (CHEMBL965567)
IC50
1.49±n/a nM
Citation
 Santana, L; González-Díaz, H; Quezada, E; Uriarte, E; Yáñez, M; Viña, D; Orallo, F Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem 51:6740-51 (2008) [PubMed]  Article
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50246306
Synonyms:
3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin | CHEMBL487235
Type:
Small organic molecule
Emp. Form.:
C17H13BrO3
Mol. Mass.:
345.187
SMILES:
Cc1c(OCC(Br)=C)ccc2c3ccccc3c(=O)oc12
Structure:
Search PDB for entries with ligand similarity: