Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50274368
Substrate
n/a
Meas. Tech.
ChEMBL_536756 (CHEMBL984550)
IC50
59±n/a nM
Citation
Montalban, AG; Boman, E; Chang, CD; Ceide, SC; Dahl, R; Dalesandro, D; Delaet, NG; Erb, E; Gibbs, A; Kahl, J; Kessler, L; Lundström, J; Miller, S; Nakanishi, H; Roberts, E; Saiah, E; Sullivan, R; Wang, Z; Larson, CJ 'Reverse' alpha-ketoamide-based p38 MAP kinase inhibitors. Bioorg Med Chem Lett 18:5456-9 (2008) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Inhibitor
Name:
BDBM50274368
Synonyms:
2-(5-tert-butyl-2-methylfuran-3-yl)-N-(4-(6-(morpholinomethyl)pyridin-3-yl)naphthalen-1-yl)-2-oxoacetamide | CHEMBL484550
Type:
Small organic molecule
Emp. Form.:
C31H33N3O4
Mol. Mass.:
511.6114
SMILES:
Cc1oc(cc1C(=O)C(=O)Nc1ccc(-c2ccc(CN3CCOCC3)nc2)c2ccccc12)C(C)(C)C