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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50198370
Substrate
n/a
Meas. Tech.
ChEMBL_558903 (CHEMBL1022582)
IC50
20±n/a nM
Citation
 Ozawa, T; Tsuji, E; Ozawa, M; Handa, C; Mukaiyama, H; Nishimura, T; Kobayashi, S; Okazaki, K The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase. Bioorg Med Chem 16:10311-8 (2008) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50198370
Synonyms:
CHEMBL223873 | N-(2,6-dimethyl-phenyl)-5-phenylimidazo[1,5-a]pyrazine-8-amine | N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine | N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazine-8-amine
Type:
Small organic molecule
Emp. Form.:
C20H18N4
Mol. Mass.:
314.3837
SMILES:
Cc1cccc(C)c1Nc1ncc(-c2ccccc2)n2cncc12
Structure:
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