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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50259548
Substrate
n/a
Meas. Tech.
ChEMBL_544238 (CHEMBL1010713)
IC50
12.6±n/a nM
Citation
 Hall, A; Brown, SH; Budd, C; Clayton, NM; Giblin, GM; Goldsmith, P; Hayhow, TG; Hurst, DN; Naylor, A; Anthony Rawlings, D; Scoccitti, T; Wilson, AW; Winchester, WJ Discovery of GSK345931A: An EP(1) receptor antagonist with efficacy in preclinical models of inflammatory pain. Bioorg Med Chem Lett 19:497-501 (2008) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_RAT | Prostanoid EP1 receptor | Ptger1
Type:
Enzyme
Mol. Mass.:
43080.10
Organism:
Rattus norvegicus (Rat)
Description:
P70597
Residue:
405
Sequence:
MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
  
Inhibitor
Name:
BDBM50259548
Synonyms:
6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-2-carboxylate Sodium | CHEMBL467510 | sodium 6-(5'-chloro-2'-isobutoxybiphenyl-2-yl)picolinate
Type:
Small organic molecule
Emp. Form.:
C22H19ClNO3
Mol. Mass.:
380.845
SMILES:
CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(n1)C([O-])=O
Structure:
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