Reaction Details  Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50254429
Substrate
n/a
Meas. Tech.
ChEMBL_559524 (CHEMBL1018997)
IC50
15500±n/a nM
Citation
 Baek, YS; Ryu, YB; Curtis-Long, MJ; Ha, TJ; Rengasamy, R; Yang, MS; Park, KH Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. Bioorg Med Chem 17:35-41 (2008) [PubMed]  Article
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50254429
Synonyms:
CHEMBL466200 | kazinol C
Type:
Small organic molecule
Emp. Form.:
C30H40O4
Mol. Mass.:
464.6362
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#6]-[#6]-[#6]-c2cc(c(-[#8])cc2-[#8])C([#6])([#6])[#6]=[#6])cc(-[#8])c(-[#8])c1-[#6]\[#6]=[#6](\[#6])-[#6]
Structure:
Search PDB for entries with ligand similarity: