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Target
Histone deacetylase 2
Ligand
BDBM50255914
Substrate
n/a
Meas. Tech.
ChEMBL_515266 (CHEMBL991290)
IC50
870±n/a nM
Citation
 Smil, DV; Manku, S; Chantigny, YA; Leit, S; Wahhab, A; Yan, TP; Fournel, M; Maroun, C; Li, Z; Lemieux, AM; Nicolescu, A; Rahil, J; Lefebvre, S; Panetta, A; Besterman, JM; Déziel, R Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg Med Chem Lett 19:688-92 (2009) [PubMed]  Article
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50255914
Synonyms:
4-(((R)-2,3-dihydro-2-oxo-3-((thiophen-2-yl)methyl)quinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | CHEMBL518957
Type:
Small organic molecule
Emp. Form.:
C21H19N3O3S
Mol. Mass.:
393.459
SMILES:
ONC(=O)c1ccc(CN2[C@H](Cc3cccs3)C(=O)Nc3ccccc23)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: