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Target
Histone deacetylase 8
Ligand
BDBM50255852
Substrate
n/a
Meas. Tech.
ChEMBL_515268 (CHEMBL991292)
IC50
730±n/a nM
Citation
 Smil, DV; Manku, S; Chantigny, YA; Leit, S; Wahhab, A; Yan, TP; Fournel, M; Maroun, C; Li, Z; Lemieux, AM; Nicolescu, A; Rahil, J; Lefebvre, S; Panetta, A; Besterman, JM; Déziel, R Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg Med Chem Lett 19:688-92 (2009) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50255852
Synonyms:
4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | CHEMBL481538
Type:
Small organic molecule
Emp. Form.:
C23H21N3O4
Mol. Mass.:
403.4305
SMILES:
ONC(=O)c1ccc(CN2[C@H](Cc3ccc(O)cc3)C(=O)Nc3ccccc23)cc1 |r|
Structure:
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