Reaction Details  Report a problem with these data
Target
Estrogen receptor beta
Ligand
BDBM50234790
Substrate
n/a
Meas. Tech.
ChEMBL_515893 (CHEMBL993947)
EC50
11±n/a nM
Citation
 Minutolo, F; Bertini, S; Granchi, C; Marchitiello, T; Prota, G; Rapposelli, S; Tuccinardi, T; Martinelli, A; Gunther, JR; Carlson, KE; Katzenellenbogen, JA; Macchia, M Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. J Med Chem 52:858-67 (2009) [PubMed]  Article
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50234790
Synonyms:
(E)-2-chloro-3,4'-dihydroxybiphenyl-4-carbaldehyde oxime | 3-chloro-4-(4-hydroxyphenyl)salicylaldoxime | CHEMBL405154
Type:
Small organic molecule
Emp. Form.:
C13H10ClNO3
Mol. Mass.:
263.676
SMILES:
Oc1ccc(cc1)-c1ccc(CN=O)c(O)c1Cl
Structure:
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