Reaction Details  Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50257895
Substrate
n/a
Meas. Tech.
ChEMBL_566300 (CHEMBL956810)
IC50
4.3±n/a nM
Citation
 Sato, N; Jitsuoka, M; Ishikawa, S; Nagai, K; Tsuge, H; Ando, M; Okamoto, O; Iwaasa, H; Gomori, A; Ishihara, A; Kanatani, A; Fukami, T Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 19:1670-4 (2009) [PubMed]  Article
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50257895
Synonyms:
4,4-bis(4-fluorophenyl)-2-(3-nitrophenyl)-4,5-dihydro-1H-imidazole | CHEMBL492594
Type:
Small organic molecule
Emp. Form.:
C21H15F2N3O2
Mol. Mass.:
379.3595
SMILES:
[O-][N+](=O)c1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1 |t:10|
Structure:
Search PDB for entries with ligand similarity: