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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50278973
Substrate
n/a
Meas. Tech.
ChEMBL_545452 (CHEMBL1032475)
IC50
1500±n/a nM
Citation
 Pegoraro, S; Lang, M; Dreker, T; Kraus, J; Hamm, S; Meere, C; Feurle, J; Tasler, S; Prütting, S; Kuras, Z; Visan, V; Grissmer, S Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett 19:2299-304 (2009) [PubMed]  Article
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50278973
Synonyms:
(5-(furan-2-carbonyl)-5,6-dihydrophenanthridin-6-yl)(2-methoxyphenyl)methanone | CHEMBL524847
Type:
Small organic molecule
Emp. Form.:
C26H19NO4
Mol. Mass.:
409.4334
SMILES:
COc1ccccc1C(=O)C1N(C(=O)c2ccco2)c2ccccc2-c2ccccc12
Structure:
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