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Target
Procathepsin L
Ligand
BDBM50257016
Substrate
n/a
Meas. Tech.
ChEMBL_562603 (CHEMBL1015279)
Ki
5900±n/a nM
Citation
 Ettari, R; Micale, N; Schirmeister, T; Gelhaus, C; Leippe, M; Nizi, E; Di Francesco, ME; Grasso, S; Zappalà, M Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors. J Med Chem 52:2157-60 (2009) [PubMed]  Article
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50257016
Synonyms:
(4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid (3R)-2-oxo-1-[(4-oxo-pent-2-enylcarbamoyl)-methyl]-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-ylmethyl ester | CHEMBL509518
Type:
Small organic molecule
Emp. Form.:
C31H26ClF3N4O5
Mol. Mass.:
627.01
SMILES:
CC(=O)CC=CNC(=O)CN1c2ccccc2C(=N[C@H](COC(=O)Nc2ccc(Cl)cc2C(F)(F)F)C1=O)c1ccccc1 |r,w:5.5,c:18|
Structure:
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