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Target
Glucose-6-phosphatase catalytic subunit 1
Ligand
BDBM50277824
Substrate
n/a
Meas. Tech.
ChEMBL_501266 (CHEMBL976168)
IC50
79000±n/a nM
Citation
 Singh, FV; Parihar, A; Chaurasia, S; Singh, AB; Singh, SP; Tamrakar, AK; Srivastava, AK; Goel, A 5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents. Bioorg Med Chem Lett 19:2158-61 (2009) [PubMed]  Article
Target
Name:
Glucose-6-phosphatase catalytic subunit 1
Synonyms:
G6PC | G6PC1 | G6PC1_HUMAN | G6PT | Glucose-6-phosphatase
Type:
PROTEIN
Mol. Mass.:
40493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_501266
Residue:
357
Sequence:
MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEKAQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIVASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL
  
Inhibitor
Name:
BDBM50277824
Synonyms:
4'-Amino-4-fluoro-2'',4''-dimethoxy-6'-methylsulfanyl-[1,1';2',1'']terphenyl-3',5'-dicarbonitrile | CHEMBL521291
Type:
Small organic molecule
Emp. Form.:
C23H18FN3O2S
Mol. Mass.:
419.471
SMILES:
COc1ccc(c(OC)c1)-c1c(C#N)c(N)c(C#N)c(SC)c1-c1ccc(F)cc1 |(18.9,-.54,;20.24,-1.31,;21.57,-.54,;21.57,1.01,;22.9,1.77,;24.24,1,;24.24,-.53,;25.57,-1.3,;25.58,-2.84,;22.91,-1.31,;25.57,1.77,;26.9,1,;26.9,-.54,;26.89,-2.08,;28.24,1.77,;29.58,1,;28.23,3.32,;29.57,4.1,;30.89,4.88,;26.9,4.08,;26.89,5.62,;28.23,6.4,;25.57,3.31,;24.24,4.08,;24.24,5.62,;22.91,6.39,;21.58,5.62,;20.24,6.39,;21.58,4.08,;22.91,3.31,)|
Structure:
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