Reaction Details  Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50277823
Substrate
n/a
Meas. Tech.
ChEMBL_501267 (CHEMBL976169)
IC50
86000±n/a nM
Citation
 Singh, FV; Parihar, A; Chaurasia, S; Singh, AB; Singh, SP; Tamrakar, AK; Srivastava, AK; Goel, A 5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents. Bioorg Med Chem Lett 19:2158-61 (2009) [PubMed]  Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50277823
Synonyms:
4'-Amino-4''-methoxy-6'-methylsulfanyl-[1,1';2',1'']terphenyl-3',5'-dicarbonitrile | CHEMBL482965
Type:
Small organic molecule
Emp. Form.:
C22H17N3OS
Mol. Mass.:
371.455
SMILES:
COc1ccc(cc1)-c1c(C#N)c(N)c(C#N)c(SC)c1-c1ccccc1
Structure:
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