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Target
Bcl-2-like protein 1
Ligand
BDBM50259505
Substrate
n/a
Meas. Tech.
ChEMBL_500251 (CHEMBL969586)
Ki
>100000±n/a nM
Citation
 Marcaurelle, LA; Johannes, C; Yohannes, D; Tillotson, BP; Mann, D Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2. Bioorg Med Chem Lett 19:2500-3 (2009) [PubMed]  Article
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50259505
Synonyms:
(2R,3R,3aS,9bS)-N-((R)-1-benzylpyrrolidin-3-yl)-1-(cyclohexylmethyl)-3-(hydroxymethyl)-6-oxo-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide | CHEMBL467309
Type:
Small organic molecule
Emp. Form.:
C30H40N4O3
Mol. Mass.:
504.6636
SMILES:
OC[C@@H]1[C@H]2Cn3c(cccc3=O)[C@H]2N(CC2CCCCC2)[C@H]1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 |r|
Structure:
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