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Target
Beta-2 adrenergic receptor
Ligand
BDBM50267987
Substrate
n/a
Meas. Tech.
ChEMBL_520026 (CHEMBL952690)
IC50
21±n/a nM
Citation
 Marquis, RW; Lago, AM; Callahan, JF; Trout, RE; Gowen, M; DelMar, EG; Van Wagenen, BC; Logan, S; Shimizu, S; Fox, J; Nemeth, EF; Yang, Z; Roethke, T; Smith, BR; Ward, KW; Lee, J; Keenan, RM; Bhatnagar, P Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues. J Med Chem 52:3982-93 (2009) [PubMed]  Article
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50267987
Synonyms:
(+/-)-2-([3-((1,1-Dimethyl-2-[4-(methyloxy)phenyl]ethyl)amino)-2-hydroxypropyl]oxy)benzonitrile | CHEMBL504479
Type:
Small organic molecule
Emp. Form.:
C21H26N2O3
Mol. Mass.:
354.4427
SMILES:
COc1ccc(CC(C)(C)NCC(O)COc2ccccc2C#N)cc1
Structure:
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