Reaction Details  Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50280918
Substrate
n/a
Meas. Tech.
ChEMBL_36935 (CHEMBL650270)
IC50
45000±n/a nM
Citation
 Wu, MT; Ikeler, TJ; Ashton, WT; Chang, RS; Lotti, VJ; Greenlee, WJ Synthesis and structure-activity relationships of a novel series of non-peptide AT2-selective angiotensin II receptor antagonists Bioorg Med Chem Lett 3:2023-2028 (1993)    Article
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50280918
Synonyms:
4-diphenylcarbamoyl-1-pentyl(phenyl)carbamoyl-(2S)-hexahydro-2-pyrazinecarboxylic acid | CHEMBL60209
Type:
Small organic molecule
Emp. Form.:
C30H34N4O4
Mol. Mass.:
514.6154
SMILES:
CCCCCN(C(=O)N1CCN(C[C@H]1C(O)=O)C(=O)N(c1ccccc1)c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: