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Target
Type-1 angiotensin II receptor
Ligand
BDBM50282284
Substrate
n/a
Meas. Tech.
ChEMBL_36945 (CHEMBL648848)
IC50
4.6±n/a nM
Citation
 Mantlo, NB; Kim, D; Ondeyka, D; Chang, RS; Kivlighn, SD; Siegl, PK; Greenlee, WJ Imidazo[4,5-b]pyridine-based AT1 / AT2 angiotensin II receptor antagonists Bioorg Med Chem Lett 4:17-22 (1994)    Article
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50282284
Synonyms:
CHEMBL308238 | N-[3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridin-6-yl]-butyramide
Type:
Small organic molecule
Emp. Form.:
C34H35N5O4S
Mol. Mass.:
609.738
SMILES:
CCCC(=O)Nc1cnc2n(Cc3ccc(cc3)-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)c(CCC)nc2c1C
Structure:
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