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Target
Type-1 angiotensin II receptor
Ligand
BDBM50282361
Substrate
n/a
Meas. Tech.
ChEMBL_36948 (CHEMBL648851)
IC50
83±n/a nM
Citation
 Walsh, TF; Fitch, KJ; MacCoss, M; Chang, RS; Kivlighn, SD; Lotti, VJ; Siegl, PK; Patchett, AA; Greenlee, WJ Synthesis of new imidazo[1,2-b]pyridazine isosteres of potent imidazo[4,5-b]pyridine angiotensin II antagonists Bioorg Med Chem Lett 4:219-222 (1994)    Article
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50282361
Synonyms:
4'-(2-Ethyl-6,8-dimethyl-imidazo[1,2-b]pyridazin-3-ylmethyl)-biphenyl-2-carboxylic acid | CHEMBL71730
Type:
Small organic molecule
Emp. Form.:
C24H23N3O2
Mol. Mass.:
385.4583
SMILES:
CCc1nc2c(C)cc(C)nn2c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Structure:
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