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Target
Type-2 angiotensin II receptor
Ligand
BDBM50282359
Substrate
n/a
Meas. Tech.
ChEMBL_35439 (CHEMBL643799)
IC50
>10±n/a nM
Citation
 Walsh, TF; Fitch, KJ; MacCoss, M; Chang, RS; Kivlighn, SD; Lotti, VJ; Siegl, PK; Patchett, AA; Greenlee, WJ Synthesis of new imidazo[1,2-b]pyridazine isosteres of potent imidazo[4,5-b]pyridine angiotensin II antagonists Bioorg Med Chem Lett 4:219-222 (1994)    Article
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50282359
Synonyms:
4'-(2-Ethyl-6,8-dimethyl-imidazo[1,2-b]pyridazin-3-ylmethyl)-biphenyl-2-sulfonic acid benzoylamide | CHEMBL449648
Type:
Small organic molecule
Emp. Form.:
C30H28N4O3S
Mol. Mass.:
524.633
SMILES:
CCc1nc2c(C)cc(C)nn2c1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Structure:
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