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Target
Type-2 angiotensin II receptor
Ligand
BDBM50283008
Substrate
n/a
Meas. Tech.
ChEBML_35434
IC50
80±n/a nM
Citation
 Quan, ML; Olson, RE; Carini, DJ; Ellis, CD; Hillyer, GL; Lalka, GK; Liu, J; VanAtten, MK; Chiu, AT; Wong, PC; Wexler, RR; Timmermans, PB Balanced angiotensin II receptor antagonists. I. The effects of biphenyl “ortho”-substitution on AT1/AT2 affinities Bioorg Med Chem Lett 4:2011-2016 (1994)    Article
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50283008
Synonyms:
4'-(5-Acetyl-4-ethyl-2-propyl-imidazol-1-ylmethyl)-biphenyl-2-sulfonic acid N-(butyloxycarbonyl)amide | CHEMBL59331
Type:
Small organic molecule
Emp. Form.:
C28H35N3O5S
Mol. Mass.:
525.66
SMILES:
CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1
Structure:
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