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Target
Type-1 angiotensin II receptor
Ligand
BDBM50283310
Substrate
n/a
Meas. Tech.
ChEBML_34645
IC50
0.540000±n/a nM
Citation
 Glinka, TW; de Laszlo, SE; Siegl, PK; Chang, RS; Kivlighn, SD; Schorn, TS; Faust, KA; Chen, TB; Zingaro, GJ; Lotti, VJ; Greenlee, WJ Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes. Bioorg Med Chem Lett 4:2337-2342 (1994)    Article
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50283310
Synonyms:
4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-4H-quinazolin-3-ylmethyl]-3'-fluoro-biphenyl-2-sulfonic acid 4-ethyl-benzoylamide | CHEMBL263452
Type:
Small organic molecule
Emp. Form.:
C37H38FN5O5S
Mol. Mass.:
683.792
SMILES:
CCc1ccc(cc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Structure:
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