Reaction Details  Report a problem with these data
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50284140
Substrate
n/a
Meas. Tech.
ChEBML_204581
IC50
>100000±n/a nM
Citation
 McDonald, IA; Nyce, PL; Muench, DM; Gates, CA; Blohm, TR; Laughlin, ME; Weintruab, PM Inhibition of steroid 5α-reductase by “inverted”, competitive inhibitors Bioorg Med Chem Lett 4:847-851 (1994)    Article
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50284140
Synonyms:
(6aS,8R,9aS,11aS)-1,9a,11a-Trimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinoline-8-carboxylic acid diisopropylamide | CHEMBL166881
Type:
Small organic molecule
Emp. Form.:
C26H44N2O2
Mol. Mass.:
416.6398
SMILES:
CC(C)N(C(C)C)C(=O)[C@@H]1C[C@@H]2CCC3C(CC[C@@]4(C)C3CCC(=O)N4C)[C@@]2(C)C1
Structure:
Search PDB for entries with ligand similarity: