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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50284141
Substrate
n/a
Meas. Tech.
ChEBML_204581
IC50
12000±n/a nM
Citation
 McDonald, IA; Nyce, PL; Muench, DM; Gates, CA; Blohm, TR; Laughlin, ME; Weintruab, PM Inhibition of steroid 5α-reductase by “inverted”, competitive inhibitors Bioorg Med Chem Lett 4:847-851 (1994)    Article
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50284141
Synonyms:
(7S,9aR,11aS)-7-Hydroxy-1,9a,11a-trimethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | CHEMBL353524
Type:
Small organic molecule
Emp. Form.:
C19H31NO2
Mol. Mass.:
305.4549
SMILES:
CN1C(=O)CCC2C3CCC4[C@@H](O)CC[C@]4(C)C3CC[C@]12C
Structure:
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