Reaction Details  Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50284459
Substrate
n/a
Meas. Tech.
ChEMBL_36768 (CHEMBL650291)
IC50
3400±n/a nM
Citation
 Walsh, TF; Fitch, KJ; Chang, RS; Faust, KA; Chen, TB; Kivlighn, SD; Zingaro, GJ; Lotti, VJ; Siegl, PK; Patchett, AA; Greenlee, WJ α-Phenoxyphenylacetic acid derived angiotensin II antagonists with low nanomolar AT1/AT2 receptor subtype affinity (Part II) Bioorg Med Chem Lett 5:1151-1154 (1995)    Article
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50284459
Synonyms:
CHEMBL274260 | [4-(7-Methyl-2-propyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenoxy]-phenyl-acetic acid
Type:
Small organic molecule
Emp. Form.:
C25H25N3O3
Mol. Mass.:
415.4843
SMILES:
CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(O)=O)c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: