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Target
Type-1 angiotensin II receptor
Ligand
BDBM50285344
Substrate
n/a
Meas. Tech.
ChEBML_34652
IC50
5±n/a nM
Citation
 Fitch, KJ; Walsh, TF; Patchett, AA; Chang, RS; Siegl, PK; Faust, KA; Chen, TB; Lotti, VJ; Kivlighn, SD; Zingaro, GJ; Greenlee, WJ AT1 selective angiotensin II antagonists with phenoxyphenylacetic acid as a biphenyl replacement part I Bioorg Med Chem Lett 5:155-158 (1995)    Article
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50285344
Synonyms:
CHEMBL40585 | [4-(7-Methyl-2-propyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenoxy]-o-tolyl-acetic acid
Type:
Small organic molecule
Emp. Form.:
C26H27N3O3
Mol. Mass.:
429.5109
SMILES:
CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(O)=O)c2ccccc2C)cc1
Structure:
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