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Target
Substance-P receptor
Ligand
BDBM50286412
Substrate
n/a
Meas. Tech.
ChEBML_208671
IC50
240±n/a nM
Citation
 Barrow, CJ; Musza, LL; Cooper, R Structure-activity studies of the natural product substance P antagonist win 64821 Bioorg Med Chem Lett 5:377-380 (1995)    Article
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50286412
Synonyms:
(3S,5aR,11aS,3'S,5'aR,11'aS)-3,3'-Dibenzyl-2,3,5a,6,11,11a,2',3',5'a,6',11',11'a-dodecahydro-[10b,10'b]bi[pyrazino[1',2':1,5]pyrrolo[2,3-b]indolyl]-1,4,1',4'-tetraone | CHEMBL124066
Type:
Small organic molecule
Emp. Form.:
C40H36N6O4
Mol. Mass.:
664.7516
SMILES:
O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1([C@@H]2Nc2ccccc12)C12C[C@@H]3N([C@H]1Nc1ccccc21)C(=O)[C@H](Cc1ccccc1)NC3=O
Structure:
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