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Target
Cathepsin B
Ligand
BDBM50286434
Substrate
n/a
Meas. Tech.
ChEBML_47409
IC50
25000±n/a nM
Citation
 Graybill, TL; Dolle, RE; Osifo, IK; Schmidt, SJ; Gregory, JS; Harris, AL; Miller, MS Inhibition of human erythrocyte calpain I by novel quinolinecarboxamides Bioorg Med Chem Lett 5:387-392 (1995)    Article
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50286434
Synonyms:
1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl-1,4-dihydro-quinoline-3-carboxylic acid amide | CHEMBL340384
Type:
Small organic molecule
Emp. Form.:
C21H14ClN3O3
Mol. Mass.:
391.807
SMILES:
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1
Structure:
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