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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50286542
Substrate
n/a
Meas. Tech.
ChEBML_195377
IC50
1250±n/a nM
Citation
 Young, SD; Amblard, MC; Britcher, SF; Grey, VE; Tran, LO; Lumma, WC; Huff, JR; Schleif, WA; Emini, EE; O'Brien, JA; Pettibone, DJ 2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase Bioorg Med Chem Lett 5:491-496 (1995)    Article
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50286542
Synonyms:
3-Benzenesulfonyl-5-chloro-2-(4,5-dihydro-thiazol-2-yl)-1H-indole | CHEMBL144742
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O2S2
Mol. Mass.:
376.88
SMILES:
Clc1ccc2[nH]c(C3=NCCS3)c(c2c1)S(=O)(=O)c1ccccc1 |t:7|
Structure:
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