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Target
Squalene synthase
Ligand
BDBM50288123
Substrate
n/a
Meas. Tech.
ChEBML_202101
IC50
15±n/a nM
Citation
 Brinkman, JA; Damon, RE; Fell, JB; Perez, LB; Scallen, TJ; Vedamanda, TR Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine Bioorg Med Chem Lett 6:2491-2494 (1996)    Article
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50288123
Synonyms:
CHEMBL82277 | [2-(4-Benzyloxy-phenoxy)-ethyl]-phenethyl-amine
Type:
Small organic molecule
Emp. Form.:
C23H25NO2
Mol. Mass.:
347.4501
SMILES:
C(COc1ccc(OCc2ccccc2)cc1)NCCc1ccccc1
Structure:
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