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Target
Squalene synthase
Ligand
BDBM50047461
Substrate
n/a
Meas. Tech.
ChEBML_202101
IC50
100±n/a nM
Citation
 Brinkman, JA; Damon, RE; Fell, JB; Perez, LB; Scallen, TJ; Vedamanda, TR Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine Bioorg Med Chem Lett 6:2491-2494 (1996)    Article
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50047461
Synonyms:
Benzyl-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-amine | Benzyl-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-amine | CHEMBL37505
Type:
Small organic molecule
Emp. Form.:
C22H33N
Mol. Mass.:
311.5041
SMILES:
[#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-[#6]-c1ccccc1
Structure:
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