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Target
Substance-K receptor
Ligand
BDBM50290462
Substrate
n/a
Meas. Tech.
ChEBML_142721
Ki
5.6±n/a nM
Citation
 Fauchère, JL; Kucharczyk, N; Jacoby, E; Lonchampt, M; Robineau, P; Dacquet, C; Regoli, D; Canet, E The dipeptide neurokinin-1 receptor antagonist S19752 is a potent and long-acting inhibitor of bronchoconstriction when administered by aerosol to the guinea pig in vivo Bioorg Med Chem Lett 7:203-208 (1997)    Article
Target
Name:
Substance-K receptor
Synonyms:
NK2R_RABIT | Neurokinin 2 receptor | TAC2R | TACR2
Type:
n/a
Mol. Mass.:
43141.28
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
384
Sequence:
MGACDIVTEANISSDIDSNATGVTAFSMPGWQLALWATAYLALVLVAVVGNATVIWIILAHRRMRTVTNYFIVNLALADLCMATFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSGPGTKAVIAGIWLVALALAFPQCFYSTITMDQGATKCVVAWPEDSGGKMLLLYHLTVIALIYFLPLVVMFVAYSVIGFKLWRRTVPGHQTHGANLRHLRAKKKFVKTMVLVVVTFAVCWLPYHLYFLLGHFQDDIYCRKFIQQVYLVLFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSLSVRVNRCHTKETLFLVGDVAPSEAANGQAGGPQDGGAYDF
  
Inhibitor
Name:
BDBM50290462
Synonyms:
CHEMBL305119 | potassium 2N-[1-benzyl(methyl)carbamoyl-2-(2-naphthyl)-(1S)-ethyl]-4-hydroxy-1-{1-[4-(1H-1,2,3,4-tetraazol-5-yl)butyl]-1H-3-indolylcarbonyl}-(2R,4S)-tetrahydro-1H-2-pyrrolecarboxamide
Type:
Small organic molecule
Emp. Form.:
C40H41N8O4
Mol. Mass.:
697.8053
SMILES:
CN(Cc1ccccc1)C(=O)C(Cc1ccc2ccccc2c1)NC(=O)C1CC(O)CN1C(=O)c1cn(CCCCc2nn[n-]n2)c2ccccc12
Structure:
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