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Target
Cyclin-dependent kinase 4
Ligand
BDBM50293160
Substrate
n/a
Meas. Tech.
ChEMBL_496923 (CHEMBL1002018)
IC50
45±n/a nM
Citation
 Stevens, KL; Reno, MJ; Alberti, JB; Price, DJ; Kane-Carson, LS; Knick, VB; Shewchuk, LM; Hassell, AM; Veal, JM; Davis, ST; Griffin, RJ; Peel, MR Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg Med Chem Lett 18:5758-62 (2009) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50293160
Synonyms:
4-(6-isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine | CHEMBL496162
Type:
Small organic molecule
Emp. Form.:
C24H28N8O
Mol. Mass.:
444.5321
SMILES:
CC(C)Oc1ccc2c(cnn2n1)-c1ccnc(Nc2ccc(cc2)N2CCN(C)CC2)n1
Structure:
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