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Target
Histone deacetylase 2
Ligand
BDBM50293357
Substrate
n/a
Meas. Tech.
ChEMBL_571846 (CHEMBL1034714)
IC50
460±n/a nM
Citation
 Dallavalle, S; Cincinelli, R; Nannei, R; Merlini, L; Morini, G; Penco, S; Pisano, C; Vesci, L; Barbarino, M; Zuco, V; De Cesare, M; Zunino, F Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem 44:1900-12 (2009) [PubMed]  Article
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50293357
Synonyms:
CHEMBL565140 | N-Hydroxy-E-3-[3'-chloro-4'-hydroxybiphenyl-4-yl]-acrylamide
Type:
Small organic molecule
Emp. Form.:
C15H12ClNO3
Mol. Mass.:
289.714
SMILES:
ONC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(Cl)c1
Structure:
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