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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50293512
Substrate
n/a
Meas. Tech.
ChEMBL_570543 (CHEMBL1026915)
IC50
>3200±n/a nM
Citation
 Cameron, KO; Lefker, BA; Ke, HZ; Li, M; Zawistoski, MP; Tjoa, CM; Wright, AS; DeNinno, SL; Paralkar, VM; Owen, TA; Yu, L; Thompson, DD Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett 19:2075-8 (2009) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_RAT | Prostanoid EP2 receptor | Ptger2
Type:
PROTEIN
Mol. Mass.:
39786.37
Organism:
Rattus norvegicus
Description:
ChEMBL_1501400
Residue:
357
Sequence:
MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
  
Inhibitor
Name:
BDBM50293512
Synonyms:
3-(3-((N-(4-tert-butylbenzyl)-4-chlorophenylsulfonamido)methyl)phenyl)propanoic acid | CHEMBL549530
Type:
Small organic molecule
Emp. Form.:
C27H30ClNO4S
Mol. Mass.:
500.049
SMILES:
CC(C)(C)c1ccc(CN(Cc2cccc(CCC(O)=O)c2)S(=O)(=O)c2ccc(Cl)cc2)cc1
Structure:
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