Reaction Details
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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50225188
Substrate
n/a
Meas. Tech.
ChEMBL_572371 (CHEMBL1035272)
pH
7.4±n/a
Ki
29000±n/a nM
Comments
extracted
Citation
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More Info.:
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
Inhibitor
Name:
BDBM50225188
Synonyms:
(2-(2-amino-6-oxo-1,6,7,8-tetrahydropurin-9-yl)ethoxy)methylphosphonate | 4-Fluoro-phenol | 4-fluorophenol | CHEMBL559509 | CHEMBL56226 | SR-1C10
Type:
Small organic molecule
Emp. Form.:
C8H14N5O5P
Mol. Mass.:
291.201
SMILES:
Nc1nc2N(CCOCP(O)(O)=O)CNc2c(=O)[nH]1