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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM50296004
Substrate
n/a
Meas. Tech.
ChEMBL_579226 (CHEMBL1058020)
IC50
63±n/a nM
Citation
 Hammond, M; Washburn, DG; Hoang, HT; Manns, S; Frazee, JS; Nakamura, H; Patterson, JR; Trizna, W; Wu, C; Azzarano, LM; Nagilla, R; Nord, M; Trejo, R; Head, MS; Zhao, B; Smallwood, AM; Hightower, K; Laping, NJ; Schnackenberg, CG; Thompson, SK Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors. Bioorg Med Chem Lett 19:4441-5 (2009) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM50296004
Synonyms:
2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)acetic acid | CHEMBL549906 | [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid
Type:
Small organic molecule
Emp. Form.:
C25H18N2O2
Mol. Mass.:
378.4226
SMILES:
OC(=O)Cc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc2ccccc2c1
Structure:
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