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Target
Carboxypeptidase B
Ligand
BDBM50296432
Substrate
n/a
Meas. Tech.
ChEMBL_580862 (CHEMBL1064194)
Ki
292000±n/a nM
Citation
 Fernández, D; Avilés, FX; Vendrell, J A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. Eur J Med Chem 44:3266-71 (2009) [PubMed]  Article
Target
Name:
Carboxypeptidase B
Synonyms:
CBPB1_HUMAN | CPB | CPB1 | Carboxypeptidase B | PASP | PCPB | Pancreas-specific protein | Thrombin-activatable fibrinolysis (TAFI)
Type:
Enzyme
Mol. Mass.:
47367.43
Organism:
Homo sapiens (Human)
Description:
P15086
Residue:
417
Sequence:
MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY
  
Inhibitor
Name:
BDBM50296432
Synonyms:
CHEMBL552272 | N-(2-(2-(2-(4-methoxyphenyl)-2-oxoethyl)-2H-tetrazol-5-yl)phenyl)cyclopropanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C20H19N5O3
Mol. Mass.:
377.3966
SMILES:
COc1ccc(cc1)C(=O)Cn1nnc(n1)-c1ccccc1NC(=O)C1CC1
Structure:
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