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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50297073
Substrate
n/a
Meas. Tech.
ChEMBL_580989 (CHEMBL1057277)
IC50
70±n/a nM
Citation
 Kishino, H; Moriya, M; Sakuraba, S; Sakamoto, T; Takahashi, H; Suzuki, T; Moriya, R; Ito, M; Iwaasa, H; Takenaga, N; Ishihara, A; Kanatani, A; Sato, N; Fukami, T Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists. Bioorg Med Chem Lett 19:4589-93 (2009) [PubMed]  Article
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50297073
Synonyms:
CHEMBL564106 | N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(4-fluorophenyl)pyrazine-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C22H18FN5O
Mol. Mass.:
387.4096
SMILES:
Cc1c(nc2ccc(NC(=O)c3cnc(cn3)-c3ccc(F)cc3)cn12)C1CC1
Structure:
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