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Target
Histone deacetylase 2
Ligand
BDBM50297446
Substrate
n/a
Meas. Tech.
ChEMBL_585885 (CHEMBL1053556)
IC50
590.00±n/a nM
Citation
 Giannini, G; Marzi, M; Marzo, MD; Battistuzzi, G; Pezzi, R; Brunetti, T; Cabri, W; Vesci, L; Pisano, C Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett 19:2840-3 (2009) [PubMed]  Article
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50297446
Synonyms:
CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-3-yl)heptanamide | ST-5732
Type:
Small organic molecule
Emp. Form.:
C23H23N5O6
Mol. Mass.:
465.4586
SMILES:
ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Structure:
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