Reaction Details  Report a problem with these data
Target
Histone deacetylase 11
Ligand
BDBM50297447
Substrate
n/a
Meas. Tech.
ChEMBL_585894 (CHEMBL1053565)
IC50
410.00±n/a nM
Citation
 Giannini, G; Marzi, M; Marzo, MD; Battistuzzi, G; Pezzi, R; Brunetti, T; Cabri, W; Vesci, L; Pisano, C Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett 19:2840-3 (2009) [PubMed]  Article
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50297447
Synonyms:
3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacrylamide | CHEMBL564382 | ST-2887
Type:
Small organic molecule
Emp. Form.:
C26H21N3O2
Mol. Mass.:
407.4638
SMILES:
ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: